We researched every real men's health and testosterone clinic we could find in Orange County, verified each one against its live website, and ranked the best on how clearly and credibly they present the practice, who oversees care, and how transparent they are. Here are 14 worth knowing, plus four honorable mentions.
How we ranked them (the published criteria)
- Physician oversight and credentialsIs a licensed MD or DO named and visible, with a real background, and if the provider is a nurse practitioner or physician assistant, do they say so plainly?
- Real labs and protocolsDo they test your hormones properly and explain the protocol, instead of a one-size-fits-all questionnaire and a needle?
- TransparencyIs the pricing, what is included, and the model (cash-pay versus insurance) clear before you ever pick up the phone?
- Brand and clarityCan a busy man understand what they offer and why in about 30 seconds?
- Trust signalsReal reviews, a real address, named providers, and no hype or miracle language.
- Booking frictionHow many clicks from the homepage to an actual scheduled consultation?
Nobody paid to be here, and we have no relationship with any clinic on this list. We simply looked at what any Orange County man would see when he starts researching, and asked which practices earn the click.
1. AsandraMD Anti-Aging · Newport Beach
What they do: TRT and bioidentical hormone therapy for men, including testosterone pellets, plus peptides, GLP-1 weight loss, and sexual wellness.
Why they stand out: Led by medical director Christopher Asandra, MD, this is an established anti-aging practice with a second Beverly Hills location, a clean Newport Beach TRT page, and both in-office and virtual consults. The physician is front and center, not buried three clicks deep.
The standout: A polished, physician-led anti-aging brand with pellet therapy and a real medical director you can actually find on the site. Visit AsandraMD Anti-Aging →
2. Newport Men's HRT · Newport Beach
What they do: A men-only hormone clinic: testosterone replacement, HCG, hGH, and anti-estrogen therapy, plus semaglutide for weight loss.
Why they stand out: Dr. Cameron Khavarian, MD (internal medicine, roughly 15 years, with former Hoag and Mission Hospital privileges) personally sees every patient at every visit. The whole site is built around one idea, men's hormones, and it shows.
The standout: A focused, men-only concierge practice where you see the same MD every single time. Visit Newport Men's HRT →
3. Dr. Bar MD · Newport Beach
What they do: Men's TRT and hormone optimization paired with regenerative medicine (peptides, PRP, the P-Shot) and aesthetics.
Why they stand out: Dr. Iman Bar, MD brings a hematology-oncology and stem-cell background, and the practice runs Newport-specific TRT landing pages that combine hormones and regenerative care under one roof. The local pages are built to be found.
The standout: Hormones and regenerative medicine in one practice, with dedicated TRT pages that actually rank locally. Visit Dr. Bar MD →
4. The Pur Health · Irvine
What they do: Physician-led TRT inside a family-medicine practice, using full CLIA lab panels and bioidentical testosterone, alongside HRT, GLP-1 weight loss, and aesthetics.
Why they stand out: Dr. Sabeen Munib, MD (15+ years) runs one of the few OC hormone practices that is in-network with major plans (Mission and Providence, Monarch and Optum, Prospect) and is openly multilingual. TRT here starts with real labs, not a quick questionnaire.
The standout: A rare TRT option that runs on real lab panels and actually takes insurance. Visit The Pur Health →
5. Castellano Health Institute · Garden Grove
What they do: Men's TRT plus ED treatment, peptides, weight loss, and thyroid support, on a fee-for-service model.
Why they stand out: Dr. Phillip Castellano is board-certified in family medicine and anti-aging (UC Irvine MD, practicing men's health since 1999) and publishes a flat $250 a month that includes medication, lab work, and monthly follow-up, with no contracts or add-ons. The pricing is right on the site.
The standout: Transparent flat-rate pricing and the same physician at every visit, since 1999. Visit Castellano Health Institute →
6. iThriveMD · Laguna Niguel
What they do: A longevity and hormone-optimization clinic: TRT (including enclomiphene), bioidentical HRT, GLP-1 weight loss, NAD+, and IV therapy.
Why they stand out: Founded by cardiovascular specialist Dr. Samir Damani, MD, this cash-pay group publishes its starting prices (TRT from $289 a month), stays open seven days a week, and operates eight locations. You know the cost before you call.
The standout: Transparent longevity pricing and seven-day access from a physician-founded group. Visit iThriveMD →
7. Gameday Men's Health · Newport Beach, Huntington Beach, Tustin & Laguna Hills
What they do: A modern men's-health franchise: TRT (injections, pellets, enclomiphene), ED care, GLP-1 weight loss, and peptides, with on-site testosterone and PSA labs that return results in about 15 minutes.
Why they stand out: Four Orange County locations, a consistent membership-style model, and same-day labs make this one of the most accessible on-ramps to TRT in the county. The experience is designed to be fast and repeatable.
The standout: On-site 15-minute labs and four OC locations, built for speed. Visit Gameday Men's Health →
8. Nexus HealthSpan · Mission Viejo
What they do: TRT and bioidentical HRT delivered inside a cardiometabolic-prevention practice, plus ED care (shockwave), weight loss, and nutrition.
Why they stand out: Founder Zachary Lott, MSN, ARNP pairs hormone care with a formal BaleDoneen arterial-disease prevention program and CIMT screening, so testosterone is managed alongside real heart-health markers rather than in a vacuum.
The standout: TRT run as part of a cardiovascular-prevention program, not in isolation. Visit Nexus HealthSpan →
9. MD Total Wellness · Brea
What they do: A physician-owned clinic: TRT and bioidentical HRT, GLP-1 weight loss, a deep peptide menu, NAD+, hair restoration, and aesthetics.
Why they stand out: Owned by David Oliak, MD with a PA-C on staff, it runs an on-site lab, same-day dispensing, and one of the most detailed peptide catalogs we found, organized by goal (healing, longevity, sexual health). Direct provider access is the pitch, and the site backs it up.
The standout: Physician-owned with an unusually deep, goal-organized peptide menu and same-day dispensing. Visit MD Total Wellness →
10. Alpha Rejuvenation · Costa Mesa
What they do: MD-supervised TRT via injections, gels, patches, and subcutaneous pellets, plus peptides, ED care, and weight loss.
Why they stand out: A men's-focused hormone clinic with clear service pages for every delivery method, serving California and Arizona where its MDs are licensed. It explains the options instead of pushing one protocol.
The standout: Multiple testosterone delivery methods under MD supervision, clearly explained. Visit Alpha Rejuvenation →
11. Action TRT · Santa Ana
What they do: A single-focus men's TRT and hormone-optimization clinic, plus HGH and peptides, tirzepatide weight loss, shockwave, the P-Shot, and IV therapy.
Why they stand out: Led by Tyler Stanley, DMSc, MPAS, a physician assistant who markets himself as a Certified Testosteronologist, the practice has built a large following (200+ reviews) around doing one thing. In-person and virtual consults are both offered.
The standout: A single-focus TRT practice with a large review base. (Provider is a physician assistant, not an MD, which the site is clear about.) Visit Action TRT →
12. South Coast Medical Group OC · Aliso Viejo
What they do: A full-service medical group (urgent care, primary care, sports and men's health) whose men's-health line includes TRT and weight management.
Why they stand out: Led by Shannon O'Connor, MD, this brick-and-mortar practice is open seven days a week with 250+ reviews, so hormone care sits inside real, ongoing primary care rather than a standalone storefront.
The standout: TRT inside a seven-day, full-service medical group. Visit South Coast Medical Group OC →
13. American Male Medical · Irvine
What they do: A men's-health clinic: TRT and low-testosterone management, HRT, PT-141 peptides, ED and PE treatment, acoustic wave therapy, sermorelin, and GLP-1 weight loss.
Why they stand out: Operating since 1998 across four national locations, it is one of the longest-running men's-health practices in the county. Longevity in this category is itself a trust signal.
The standout: One of Orange County's longest-running men's-health practices. Visit American Male Medical →
14. UC Irvine Health, Men's Health Center · Newport Beach, Orange & Irvine
What they do: An academic urology men's-health program: TRT and low-testosterone care alongside ED, male infertility, Peyronie's disease, and prostate health.
Why they stand out: Led by Dr. Faysal Yafi, MD, FRCSC (Director of Men's Health at UCI, 250+ peer-reviewed publications) with a full urology team across three OC locations. This is the research-backed, hospital-system option for men who want hormone care inside academic medicine.
The standout: The academic, urology-backed choice for TRT in Orange County. Visit UC Irvine Health, Men's Health Center →
Four more worth a look
- Conner Wellness Center · Fountain Valley. Dr. Caroline Conner, MD offers men's TRT with lab monitoring alongside women's hormone and gynecological care, all under one roof. Visit →
- BioPrime Medical · Irvine. Dr. Bradley Noon, MD runs a telehealth-first TRT practice with published pricing (a $250 a month package including medication, lab review, and monthly check-ins). Visit →
- LiveWellMD · San Clemente. Men's testosterone and sexual-health care offered within a medical weight-loss and aesthetics clinic in south OC. Visit →
- Dr. John Laura · Newport Beach. Bioidentical testosterone therapy (injections, gels, patches) with estrogen monitoring, inside a cosmetic, anti-aging, and regenerative practice. Visit →
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Book a Strategy Call Get a free 48-hour auditQuestions men ask about TRT clinics in Orange County
What is TRT, and who is it for?
Testosterone replacement therapy is a physician-supervised treatment for men with clinically low testosterone confirmed by blood work. It is a medical treatment, not a supplement. A legitimate clinic tests your levels first, explains the risks and monitoring, and reassesses over time. Who it is right for is a decision for you and a licensed physician, not a website.
How much does TRT cost in Orange County?
Most cash-pay clinics on this list publish memberships in the range of roughly $250 to $300 a month, often including medication, labs, and follow-up. A few practices, like The Pur Health and South Coast Medical Group, work with insurance, which changes the math. Always confirm exactly what is included before you commit.
Do these clinics take insurance?
Most dedicated TRT and hormone clinics are cash-pay and do not bill insurance. The exceptions on this list are the physician practices that also do primary care, such as The Pur Health (in-network with several major plans) and South Coast Medical Group. If insurance matters to you, ask up front.
Does it matter whether an MD, a nurse practitioner, or a physician assistant runs the clinic?
It can. Many excellent clinics are led by nurse practitioners or physician assistants working within their scope, and we note the provider type in each entry so you can decide. The thing that matters most is honest disclosure: a good clinic tells you exactly who is treating you and what their credentials are.
How did PELORA choose this list?
We are a marketing agency, not a medical practice, so we did not judge clinical outcomes. We researched real Orange County clinics, verified each one against its live website, and ranked them on physician oversight, transparency, trust signals, and how clearly each presents its practice. None of these clinics is a PELORA client. If that ever changes, we will say so right in the entry.
I run one of these clinics. How do I get added, corrected, or featured?
If you belong on this list or something in your entry is out of date, email us at hello@peloramarketing.com and we will review it. If you already made the list, grab your free badge below to show it on your own site.